HETEROCYCLIC MEK INHIBITORS AND METHODS FOR USE THEREOF Russian patent published in 2013 - IPC C07D237/12 C07D237/14 A61K31/50 A61K31/4412 A61K35/00 

FIELD: chemistry.

SUBSTANCE: invention describes a compound of formula

or a pharmaceutically acceptable salt thereof, where: R¹ is O or F; R³ is H, Me, Et, OH, MeO, EtO-, HOCH₂CH₂O-, HOCH₂C(Me)₂O-, (S)-MeCH(OH)CH₂O-, (R)-HOCH₂CH(OH)CH₂O-, cyclopropyl-CH₂O-, HOCH₂CH₂-, , , , , or ; R⁷ is cyclopropyl-CH₂- or C₁-C₄alkyl, where said alkyl is optionally substituted with one or more F; R⁸ is Br, I or SMe; and R⁹ is CH₃, CH₂F, CHF₂, CF₃, F or Cl. The invention also discloses use of said compound in preparing a medicinal agent for treating a hyperproliferative disorder or an inflammatory condition, as well as a MEK inhibiting pharmaceutical composition.

EFFECT: novel compounds are obtained and described, which are MEK inhibitors and can useful in treating hyperproliferative diseases such as cancer and inflammation in mammals and inflammatory conditions.

13 cl, 25 ex, 8 tbl, 15 dwg