AZABENZOFURANYL COMPOUNDS AND METHODS OF USE Russian patent published in 2012 - IPC C07D491/48 A61K31/4355 A61K31/444 A61K31/4545 A61K31/5377 A61K31/541 A61P1/18 A61P13/12 A61P19/08 A61P25/28 A61P29/00 A61P31/00 A61P31/12 A61P35/00 A61P37/02 

FIELD: chemistry.

SUBSTANCE: invention relates to azabenzofuranyl compounds of formula I and salts thereof, where: Z¹ denotes CR¹, Z² denotes N, Z³ denotes CR³, Z⁴ denotes CR⁴, R¹, R³ and R⁴ are independently selected from H, halogen, CN, -(CR¹⁴R¹⁵)_nC(=Y)OR¹¹, - (CR¹⁴R¹⁵)_nOR¹¹, C₁-C₁₂ alkyl; W denotes or R⁵ and R⁶ are independently selected from H or C₁-C₁₂ alkyl; X¹ is selected from R¹¹, -OR¹¹ and -S(O)₂R¹¹; if X¹ denotes R¹¹ or -OR¹¹ from X¹ and -R⁵ optionally taken together with a nitrogen atom with which they are bonded form a 4-6-member saturated or unsaturated ring containing 0-2 additional heteroatoms selected from O, S, where said ring is optionally substituted with one or more groups selected from oxo, -(CR¹⁹R²⁰)_nNR¹⁶R¹⁷, -(CR¹⁹R²⁰)_nOR¹⁶, (CR¹⁹R²⁰)_nS(O)₂R¹⁶ and R²¹; X is selected from aryl, where said aryl is optionally substituted with one or more groups selected from halogen, CN, -Si(C₁-C₆alkyl), -(CR¹⁹R²⁰)_nOR¹⁶, -(CR¹⁹R²⁰)_nSR¹⁶, C₁-C₁₂alkyl; R¹¹, R¹² and R¹³ independently denote H, C₁-C₁₂alkyl, aryl, azetidine, pyrrolidinyl, piperidinyl, tetrahydropyranyl; R¹⁴ and R¹⁵ are independently selected from H or C₁-C₁₂ alkyl; n is independently selected from 0, 1; Y independently denotes O; where each of said alkyl, alkenyl, aryl and heteroaryl from R¹, R², R³, R⁴, R⁵, R⁶, X¹, X², R¹¹, R¹², R¹³, R¹⁴ and R¹⁵ is independently and optionally substituted with one or more groups independently selected from -(CR¹⁹R²⁰)_nC(=Y')OR¹⁶, -(CR¹⁹R²⁰)_nNR¹⁶R¹⁷, -(CR¹⁹R²⁰)_nOR¹⁶, -(CR¹⁹R²⁰)_nNR¹⁶C(=Y')R¹⁷, -(CR¹⁹R²⁰)_nNR¹⁶C(=Y')OR¹⁷, - (CR¹⁹R²⁰)_nNR¹⁷SO₂R¹⁶ and R²¹; each R¹⁶, R¹⁷ independently denotes H, C₁-C₁₂ alkyl, C₂-C₈alkenyl, aryl, or pyridinyl, where said alkyl, alkenyl or aryl is optionally substituted with one or more groups selected from -OH; R¹⁹ and R²⁰ are independently selected from H, C₁-C₁₂ alkyl; R²¹ denotes C₁-C₁₂ alkyl, aryl, imidazolyl, pyridinyl, pyrazolyl, pyrrolidinyl, 2-oxo-pyrrolidinyl, piperidinyl, or 2,2-dimethyl-1,3-dioxolanyl; each Y' independently denotes O. The invention also relates to specific compounds, a pharmaceutical composition based on the disclosed compounds, a method of inhibiting anomalous cell growth or a method of treating hyperproliferative disorders, inflammatory diseases and other diseases.

EFFECT: novel azabenzofuranyl derivatives which can be used in treating cancer and inflammatory diseases are obtained.

23 cl, 3 tbl, 34 ex