NOVEL SUBSTITUTED PYRIDIN-2-ONES AND PYRIDAZIN-3-ONES Russian patent published in 2013 - IPC C07D413/14 C07D417/14 C07D401/10 C07D401/14 C07D403/14 A61K31/501 A61K31/502 A61P29/00 A61P37/06 

FIELD: chemistry.

SUBSTANCE: invention relates to novel pyridin-2-one and pyridazin-3-one derivatives, having Btk inhibiting activity. In formulae I-IV:

,

R denotes -R¹-R²-R³ or -R²-R³; R¹ denotes a heteroaryl containing 6 ring atoms, including one N heteroatom; R² denotes -C(=O), -C(=O)N(R²'), where R²' denotes H; R³ denotes R⁴; where R⁴ is a lower alkyl, heterocycloalkyl, (lower alkyl) heterocycloalkyl or heterocycloalkyl (lower alkyl), where the heterocycloalkyl contains 6 ring atoms, including two heteroatoms selected from N and O; and where R⁴ can be substituted with one or more substitutes selected from lower alkyl, oxo group and lower alkoxy group; X denotes CH or N; Y¹ denotes lower alkyl; n and m are equal to 0; values of radicals Y², Y⁴ are given in the claim.

EFFECT: improved properties of compounds.

6 cl, 2 tbl, 42 ex