METHOD FOR DETERMINING INDIVIDUAL SENSITIVITY OF HUMAN GENOME TO HIGH DOSES OF RADON AND ITS DISINTEGRATION PRODUCTS Russian patent published in 2013 - IPC G01N33/50 

FIELD: medicine.

SUBSTANCE: what is presented is a method for determining the individual sensitivity of human genome to high doses of radon and its disintegration products. Buccal epitheliocytes are examined for predisposing and protective genotypes: marker Arg399Gln of gene Arg/Arg; marker Argl94Trp of gene XRCC1 -predisposing genotype Arg/Trp; marker Glul85Gln of gene NBS1 -predisposing genotype Glu/Gln, protective genotype Glu/Glu; marker Ser326Cys of gene hOGG1 - predisposing genotype Ser/Cys; marker -Asp 1853Asn of gene ATM- predisposing genotype Asp/Asp, protective genotype Asp/Asn; marker Asp1104His of gene XPG - protective genotype His/His. The prevalence of predisposing genotypes or the equal quantity of predisposing and protective genotypes enable stating the high individual sensitivity to high radon doses and predicting the micronucleus and protrusion accumulations. The quantitative prevalence of protective genotypes enables stating the high individual sensitivity to radon and predicting the resistance to the micronucleus and protrusion accumulation.

EFFECT: use of the method allows estimating genetically determined predisposition to formation of high level of micronuclei and protrusions even before exposing to a radiating factor.

2 cl, 5 tbl, 2 ex