GLUCOCORTICOIDS CONNECTED BY MEANS OF AROMATIC LINKER IN POSITION 21 TO NITRATE ESTERS, AND THEIR APPLICATION IN OPTHALMOLOGY Russian patent published in 2013 - IPC C07J41/00 C07J71/00 A61K31/537 A61P27/00 A61P5/44 

FIELD: biotechnologies.

SUBSTANCE: in general formula (I), R₁ and R₂ that have been taken jointly are a group of formula (II), R₃ represents atom of hydrogen or F and R₄ represents F; R₁, R₂, R₃ and R₄ are connected to 17, 16, 6 and 9 carbon atoms of steroid structure in position α or β; R represents (III) or (IV), and the rest values of radicals are given in the description.

EFFECT: improving use efficiency of compositions for curing of eye diseases, such as diabetic macular edema, diabetic retinopathy, macular degeneration, age-related macular degeneration and other macular and retina diseases.

11 cl, 4 dwg, 5 tbl, 11 ex