FIELD: biotechnologies.
SUBSTANCE: invention proposes a method for obtaining an expression vector coding an adapted recombinase. The above adapted recombinase recombines asymmetric sections-targets in LTR of proviral DNA of retrovirus built into a genome of a host cell and applicable as means for cutout of provirus from genome of the host cell.
EFFECT: optimisation of curing of retroviral infection with individual in vitro and use of adapted recombinases for obtaining pharmaceutical compositions for reduction of virus load with the individual infected with retrovirus.
21 cl, 11 dwg, 1 tbl, 4 ex
| Title | Year | Author | Number |
|---|---|---|---|
| ADAPTED RECOMBINASE FOR ASYMMETRIC TARGET SITE RECOMBINATION IN A VARIETY OF RETROVIRUSES STRAINS | 2011 |
|
RU2617968C2 |
| WELL TOLERABLE AND HIGHLY SPECIFIC ADAPTED RECOMBINASE FOR RECOMBINATION OF ASYMMETRIC TARGET REGIONS IN VARIETY OF STRAINS OF RETROVIRUSES | 2015 |
|
RU2706194C2 |
| IMMORTALISED CELL LINE OF BIRDS | 2008 |
|
RU2475536C2 |
| ASLV-BASED VECTOR SYSTEM | 2010 |
|
RU2566563C2 |
| AVIAN TELOMERASE REVERSE TRANSCRIPTASE | 2007 |
|
RU2415867C2 |
| IMPROVING GENETIC CONSTRUCTS FOR PROVIDING HIGH EFFICACY OF ANTI-HIV THERAPY | 2013 |
|
RU2533817C1 |
| STABLE CELL LINES FOR RETROVIRUSES PRODUCTION | 2016 |
|
RU2752498C2 |
| SELF-INACTIVATED HELPER ADENOVIRUSES FOR PREPARING HIGH-CAPACITY RECOMBINANT ADENOVIRUSES | 2009 |
|
RU2520809C2 |
| GENETIC MAKE-UPS FOR ANTI-HIV THERAPY | 2010 |
|
RU2426788C1 |
| SUBSTRATE FOR DETERMINATION OF HUMAN IMMUNODEFICIENCY VIRUS INTEGRASE ACTIVITY | 2002 |
|
RU2234535C2 |
