FIELD: biotechnology.
SUBSTANCE: inventions relate to a method for preparation of an expression vector encoding an adapted recombinase capable of asymmetric target sequences recombination within the long terminal repeat (LTR) of the multiple HIV-1 strains proviral DNA built into the host cell genome, as well as the resulting expression vector, cells transfected by this vector, the expressed recombinase and a pharmaceutical composition comprising an expression vector, cell and/or recombinase.
EFFECT: possible use for treatment or prevention of HIV-1 infection in a subject.
28 cl, 5 dwg, 2 ex
| Title |
Year |
Author |
Number |
| WELL TOLERABLE AND HIGHLY SPECIFIC ADAPTED RECOMBINASE FOR RECOMBINATION OF ASYMMETRIC TARGET REGIONS IN VARIETY OF STRAINS OF RETROVIRUSES |
2015 |
- Hauber, Joachim
- Chemnitz, Jan
- Buchholz, Frank
- Karpinski, Janet
|
RU2706194C2 |
| APPLICATION OF ADAPTED RECOMBINASES FOR CURING OF RETROVIRAL INFECTIONS |
2008 |
- Khauber Joakhim
- Bukhkhol'Ts Frank
- Khauber Ilona
- Stjuart A. Frensis
- Sarkar Indrani
|
RU2501860C2 |
| METHOD FOR DETECTING PROVIRAL DNA OF HUMAN IMMUNODEFICIENCY VIRUS INTEGRATED INTO HUMAN GENOME IN ULTRALOW CONCENTRATIONS AND SPECIFIC OLIGONUCLEOTIDES FOR USE IN METHOD |
2019 |
- Akimkin Vasilij Gennadevich
- Tyumentsev Aleksandr Igorevich
- Tyumentseva Marina Alekseevna
|
RU2720767C1 |
| METHOD OF PRODUCING A PREPARATION OF A RIBONUCLEOPROTEIN COMPLEX OF CRISPR / CAS AND A PREPARATION FOR DETECTING PROVIRAL DNA OF HUMAN IMMUNODEFICIENCY VIRUS INTEGRATED INTO A HUMAN GENOME IN ULTRA-LOW CONCENTRATIONS |
2019 |
- Akimkin Vasilij Gennadevich
- Tyumentsev Aleksandr Igorevich
- Tyumentseva Marina Alekseevna
|
RU2720769C1 |
| CRISPR-CAS SYSTEM FOR DETECTING PROVIRAL DNA OF HUMAN IMMUNODEFICIENCY VIRUS INTEGRATED INTO A HUMAN GENOME IN ULTRA-LOW CONCENTRATIONS |
2019 |
- Akimkin Vasilij Gennadevich
- Tyumentsev Aleksandr Igorevich
- Tyumentseva Marina Alekseevna
|
RU2720768C1 |
| IMMORTALISED CELL LINE OF BIRDS |
2008 |
- Ehrb Filipp
- Kapfer Marina
- Sil'Vestr Natali
|
RU2475536C2 |
| CAS-EXPRESSING MOUSE EMBRYONIC STEM CELLS, AND MICE AND THEIR USE |
2018 |
- Gun, Gochun
- Khant, Sharlin
- Kadzhimura, Dajsuke
- Khartford, Syuzann
- Zambrovich, Brajan
|
RU2782358C2 |
| METHODS AND COMPOSITIONS FOR ASSESSMENT OF MEDIATED CRISPR/CAS DESTRUCTION OR CUTOUT AND INDUCED CRISPR/CAS RECOMBINATION WITH EXOGENEOUS DONOR NUCLEIC ACID IN VIVO |
2018 |
- Gun, Gochun
- Khant, Sharlin
- Bridzhes, Syuzanna
- Khartford, Syuzann
- Frendevej, Devid
- Zambrovich, Brajan
- Merfi, Endryu Dzh.
|
RU2782356C2 |
| ASLV-BASED VECTOR SYSTEM |
2010 |
- Aksel' Shambakh
- Kristofer Baum
- Julija Debora Zjurt
|
RU2566563C2 |
| AVIAN TELOMERASE REVERSE TRANSCRIPTASE |
2007 |
- Ehrb Filipp
- Bajjul' Zhan-Mark
- Kapfer Marina
- Sil'Vestr Natali
|
RU2415867C2 |
