SULPHONAMIDE COMPOUNDS AND USE THEREOF Russian patent published in 2013 - IPC C07C311/18 C07C311/29 C07C311/41 C07D213/36 C07D213/55 C07D213/83 C07D213/79 C07D333/24 C07D333/34 C07D409/12 A61K31/18 A61K31/195 A61K31/196 A61K31/197 A61K31/198 A61K31/216 A61K31/235 A61K31/381 A61K31/44 A61K31/4436 A61P5/20 A61P17/00 A61P17/14 A61P19/00 A61P19/10 

FIELD: chemistry.

SUBSTANCE: invention relates to sulphonamide compounds of formula or pharmaceutically acceptable salts thereof, wherein A is phenyl, optionally substituted with 1 or 2 halogen atoms, C_1-6 alkyl group, trifluoromethyl group, C_1-6 alkoxy group or -SCH₃ group, thiophenyl, optionally substituted with a C₁-C₆ alkyl group or a halogen atom, pyridinyl, optionally substituted with a halogen atom, naphthalenyl or dihydroindenyl; R¹ denotes the following formulae or [in formulae (R^1a) and (R^1b) Ar¹ denotes the following formulae , or (each R⁵ and R⁶ independently denotes a hydrogen atom, a halogen atom, a C_1-6 alkyl group optionally substituted with up to three halogen atoms, C_1-6 lower alkoxy group optionally substituted with up to three halogen atoms); Ar² denotes the following formulae , or (each R⁷ and R⁸ independently denotes a hydrogen atom, a hydroxyl group, a halogen atom, a C_1-6 alkyl group optionally substituted with up to three halogen atoms or a C_1-6 lower alkoxy group optionally substituted with up to three halogen atoms, an amine group, a nitro group, a C_2-6 acyl group, or R⁷ and R⁸ together form -CH₂CH₂O-; R⁹ is a hydrogen atom or - J-COOR¹⁰; J is a covalent bond, alkylene containing 1 to 5 carbon atoms, alkenylene containing 2 to 5 carbon atoms or alkynylene containing 2 to 5 carbon atoms, where one carbon atom in said alkylene groups can be substituted with an oxygen atom, a sulphur atom, NR¹¹, CONR¹¹ or NR¹¹CO in any chemically acceptable position; R¹¹ is a hydrogen atom; and R¹⁰ is a hydrogen atom); and p equals 0 or 1]; R² is a C_1-6 alkyl group; each R³ and R⁴ is independently a C_1-6 alkyl group; * denotes an asymmetric carbon atom; and m equals an integer from 1 to 3. The invention also relates to a medicinal agent for stimulating PTH secretion.

EFFECT: obtaining novel compounds which can be used in medicine to prevent or treat primary or secondary osteoporosis.

29 cl, 15 tbl, 14 ex