FIELD: chemistry.
SUBSTANCE: invention relates to 17-methyl-3,6-dimethoxy-7α-(trifluoroacetyl)-4,5α-epoxy-6α, 14α- ethenoisomorphinane of formula (I) 
The invention also relates to a method of producing said compound, which involves reacting an aldehyde of formula 
with a Ruppert-Prakash reagent [CF3Si(CH3)3] in the presence of an F- source and oxidising the obtained fluorine-containing alcohol of formula 
with a product of reacting oxalyl chloride and dimethylsulphoxide at low temperature in methylene chloride, followed by treating the reaction mixture with a base and separating the end product (I) using standard techniques.
EFFECT: obtaining a novel compound which can be used to produce fluorine-containing tevinols and orvinols, which can be used as an active ingredient in medicinal agents.
4 cl, 4 ex
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Year |
Author |
Number |
| 7α-(1-HYDROXY-2,2,2-TRIFLUOROETHYL)-17-METHYL-3,6-DIMETHOXY-4,5α-EPOXY-6α,14α-ETHENOISOMORPHINANE AND METHOD FOR PRODUCTION THEREOF |
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|
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