FIELD: chemistry.
SUBSTANCE: described is a method for producing 2,3-deoxy-Δ2(3)-ecdysteroids by the formula:
.
The method is implemented by a reaction of dideoxygenation of ecdysteroids in a dimethylformamide solution in the presence of a mixture of 4 mol equivalents of NaI (sodium iodide) and Zn (zinc powder) with application of ultrasound for 3 hours. The reaction mixture is then treated with water, and the products are separated by column chromatography on a silica gel.
EFFECT: method allows for effective, selective and quantitative production of configuration-homogeneous Δ2 (3)-precursors used for synthesis of biologically active steroids.
1 cl, 1 tbl, 4 ex
| Title | Year | Author | Number |
|---|---|---|---|
| METHOD OF PRODUCING METHYL-REGROUPED ECDYSTEROID 2,3:20,22-DIACETONIDE-9α,13α -EPOXY-14β -METHYL-13-DEMETHYL-14-DESOXY-7,8-DIHYDRO-20-HYDROXYECDYSONE | 2010 |
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| AGENT "EKDISTERON-80" POSSESSING CARDIOPROTECTIVE, ADAPTOGENIC, ANTI-HYPOXIC, GASTROPROTECTIVE, THERMOPROTECTIVE, ANABOLIC AND ACTOPROTECTIVE ACTIVITY AND METHOD FOR ITS PRODUCTION | 2006 |
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| AGENT FOR REGULATION OF SKIN CELLS DIFFERENTIATION, CULTURE MEDIUM FOR CELLS OR TISSUES AND METHOD OF REGULATION OF SKIN CELLS DIFFERENTIATION | 1993 |
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RU2399674C2 |
