REPLICATION INHIBITORS OF HUMAN IMMUNODEFICIENCY VIRUS Russian patent published in 2014 - IPC C07D495/04 A61K31/4365 A61P31/18 

Abstract RU 2503679 C2

FIELD: biotechnologies.

SUBSTANCE: invention refers to compounds of formula I:

, where X means S or CR5;Y means S or CR7; where one of X or Y means S; each of R2, R5, R6 and R7 has been independently chosen from a group including the following: a) halogen; b) R8, -O-R8, -(C1-C6)alkylene-R8, -(C1-C6)alkylene-O-R8; where in each case R8 has been independently chosen from a group containing H, (C1-C6)alkyl, (C2-C6)alkenyl, (C3-C7)cycloalkyl and aryl; R3 means -W-R31 and bond is an ordinary bond; where W means O and R31 means (C1-C6)alkyl, (C3-C7)cycloalkyl, (C3-C7)cycloalkyl-(C1-C6)alkyl-; R4 means aryl or Het, where each aryl and Het optionally contains 1 to 5 substitutes, each of which has been independently chosen from a group containing halogen, (C1-C6)alkyl, (C2-C6)alkenyl, (C1-C6)haloalkyl, (C3-C7)cycloalkyl, (C3-C7)cycloalkyl-(C1-C6)alkyl-, -OH, -O(C1-C6)alkyl, -NH2, -NH(C1-C6)alkyl and -N((C1-C6)alkyl)2, which can be used for treatment of HIV infection.

EFFECT: improving compound application efficiency.

15 cl, 4 tbl, 55 ex

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RU 2 503 679 C2

Authors

Karson Rebeka Zh.

Fejder Li

Kauaj Stiven

Landri Serzh

Dates

2014-01-10Published

2008-11-03Filed