METHOD FOR PREPARING POLYMER MODIFIED HEMOGLOBIN Russian patent published in 2014 - IPC A61K35/18 A61K38/42 A61P7/00 C07K14/805 

FIELD: medicine.

SUBSTANCE: invention refers to medicine, particularly to transfusion medicine, namely to a method for preparing polymer modified haemoglobin by the step multifunctional condensation of purified haemoglobin recovered from concentrated red cells in the mixed oxy/deoxy form with a synthetised multifunctional cross-linking agent that is glutaric aldehyde with glutamic acid and sodium glutamate, wherein the first stage of the reaction involves the intramolecular chemical cross-linking of a haemoglobin molecule labile in an aqueous solution; the second stage involves the intramolecular cross-linking of the ready modified haemoglobin molecules to form polymer modified haemoglobin.

EFFECT: invention provides preparing more effective polymer modified haemoglobin in the form of the multifunctional blood substitute having the effective oxygen transfer function, anti-shock and haemodynamic action able to initiate own blood formation.

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