HYDROXYLATED PYRIMIDYLCYCLOPENTANES AS PROTEIN KINASE (AKT) INHIBITORS Russian patent published in 2014 - IPC C07D239/70 A61K31/517 A61K35/00 

FIELD: chemistry.

SUBSTANCE: invention concerns novel hydroxylated pyrimidylcyclopentanes of general formula I and pharmaceutically acceptable salts thereof. The invention also relates to a pharmaceutical composition containing an effective amount of a compound of formula I, use of the compounds to produce a drug for therapy of protein kinase AKT mediated pathological conditions such as a hyperproliferative disease, particularly cancer. In formula (I):

,

R¹ is C₁-C₆ alkyl containing one substitute OH; R² is hydrogen or F; and R³ is O or CF₃. The subject of the invention is a kit containing a pharmaceutical composition and directions for use thereof.

EFFECT: compounds have protein kinase AKT selective inhibitor properties.

15 cl, 3 ex