HYDROXYLATED PYRIMIDYL CYCLOPENTANE AS PROTEINKINASE (ACT) INHIBITOR Russian patent published in 2014 - IPC C07D239/70 A61K31/517 A61P35/00 

FIELD: chemistry.

SUBSTANCE: invention relates to a novel compound, corresponding to formula I, and its pharmaceutically acceptable salts, possessing properties of a proteinkinase ACT inhibitor. The invention also relates to a pharmaceutical composition, containing efficient amount of the said compound, and a set for treatment of pathological state, mediated by proteinkinase ACT, which includes: a) one pharmaceutical composition, containing the compound by i.1 and b) an instruction for its application. Formula I compound corresponds to the structural formula:

i.e. (S)-2-(4-chloro-3-fluorophenyl)-1-(4-((5R,7R)-7-hydroxy-5-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl)piperazin-1-yl)-3-((1R,4S)-4-methoxycyclohexylamino)propan-1-one.

EFFECT: compound can be used as a medication for treatment of pathological states, mediated by proteinkinases ACT, such as inflammation, hyperproliferative, such as cancer, cardiovascular, neurodegenerative, gynaecological or dermatological disease or disorder.

9 cl, 1 ex