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2 650 511

(13)

(51)

IPC

C07D403/04(2006-01-01)

C07D239/70(2006-01-01)

A61K31/517(2006-01-01)

A61P35/00(2006-01-01)

(21) (22)

Application

2014151016, 2013-05-17

(24)

Start date

2013-05-17

(22)

Actual filing date

2013-05-17

(45)

Published

2018-04-16

(72)

Inventor

Chakravarti ParomaKotkhari SandzhivGosselen FransisSevidzh Skott Dzh.Stalts Dzheffri

(73)

Holder

Dzhenentek, Ink.

FORMS AND COMPOSITION OF PYRIMIDINYL CYCLOPENTANE COMPOUNDS, COMPOSITIONS AND METHODS THEREOF Russian patent published in 2018 - IPC C07D403/04 C07D239/70 A61K31/517 A61P35/00

Abstract RU 2650511 C2

FIELD: medicine; pharmacology.

SUBSTANCE: invention relates to amorphous (S)-2-(4-chlorophenyl)-1-(4-((5R,7R)-7-hydroxy-5-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl)piperazin-1-yl)-3-(isopropylamino)propan-1-one monohydrochloride.

EFFECT: technical result: a new amorphous (S)-2-(4-chlorophenyl)-1-(4-((5R,7R)-7-hydroxy-5-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl)piperazin-1-yl)-3-(isopropylamino)propan-1-one monohydrochloride, as well as pharmaceutical formulations based on it, possessing AKT protein kinase inhibitory activity and can be used to treat cancer.

29 cl, 11 ex, 58 dwg, 6 tbl

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RU 2 650 511 C2

Authors

Chakravarti Paroma

Kotkhari Sandzhiv

Gosselen Fransis

Sevidzh Skott Dzh.

Stalts Dzheffri

Dates

2018-04-16—Published

2013-05-17—Filed