METHOD OF PREDICTING ACHIEVEMENT OF CONTROL OVER BRONCHIAL ASTHMA Russian patent published in 2014 - IPC A61B5/91 

FIELD: medicine.

SUBSTANCE: invention relates to medicine, namely to pulmonology, and can be used for predicting achievement of control over bronchial asthma (BA). For this purpose, spirogram of quiet breathing is registered for 3 minutes in patients with mild persisting or medium-severe persisting course in attack-free period before beginning therapy. After that, standard deviation of respiratory cycle duration (SD) is calculated. Then, instantaneous volumetric rate of forced exhalation at the level of 50% vital lung capacity (IVR₅₀%) is determined. Two doses of short action β₂-agonist are introduced in inhalation way. After 15 minutes IVR₅₀% is re-registered. After that, degree of IVR₅₀% change in response to medication introduction is calculated in %. Then discriminant equation D=0.923×IVR₅₀%+68.766×SD, where D is discriminant function, with boundary value 77.0, is solved. If D value is equal or higher than boundary value, it is predicted that BA control will not be reached after 6 months of standard therapy. If D value is lower than boundary value, it is predicted that BA control will be reached.

EFFECT: method makes it possible to start adequate pharmacotherapy in patients with low probability of obtaining control over BA in due time and eliminate introduction of large doses of inhalation glucocorticosteroids to patients with predicted achievement of disease control.

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