FIELD: chemistry.
SUBSTANCE: claimed invention relates to novel pyrimidine-substituted purine compound of formula (I) or pharmaceutically acceptable salt of said compound, which possess inhibiting action with respect to mTOR and P13 kinases and can be applied in cancer treatment. Formula (I) compound corresponds to structural formula Formula (I) 
EFFECT: invention relates to pharmaceutical composition which contains therapeutically effective quantity of said compound and pharmaceutically acceptable diluents, auxiliary substance or carrier, to method of inhibition of proteinkinase, selected from mTOR or P13 kinase, and to method of treatment or prevention of state in mammal, associated with inhibition of mTOR and/or P13 kinase activity.
11 cl, 1 tbl, 3 ex
| Title |
Year |
Author |
Number |
| PYRIMIDINE-SUBSTITUTED PURINE DERIVATIVES, PHARMACEUTICAL COMPOSITION BASED THEREON, METHOD OF PROTEIN KINASE INHIBITION, METHOD OF TREATING OR PREVENTING DISEASES SENSITIVE TO PROTEIN KINASE INHIBITION AND METHOD OF TREATING PROLIFERATIVE DISEASES |
2008 |
- Nagaradzh Kharish Kumar Majsur
- Uil'Jams Meredit
|
RU2518098C2 |
| PYRIMIDINE-SUBSTITUTED DERIVATIVES OF PURINE, PHARMACEUTICAL COMPOSITION BASED THEREON, METHOD FOR INHIBITING PROTEIN KINASE, METHOD FOR TREATMENT OR PREVENTION OF DISEASES SUSCEPTIBLE TO INHIBITING PROTEIN KINASE, AND METHOD OF TREATING PROLIFERATIVE DISEASES |
2008 |
- Nagaradzh Kharish Kumar Majsur
- Uilyams Meredit
|
RU2681081C2 |
| COMBINATION OF PHOSPHATIDYL INOSITOL-3-KINASE (PI3K) INHIBITOR AND mTOR INHIBITOR |
2009 |
- Karlos Garsija-Ehcheverrija
- Sove-Mishel' Maira
|
RU2538683C2 |
| SOME CHEMICAL COMPOUNDS, COMPOSITIONS AND METHODS |
2010 |
- Ren Pingda
- Liu Ji
- Uilson Troj Edvard
- Li Liansheng
- Chan Katrina
- Rommel Kristian
|
RU2582676C2 |
| CHEMICAL COMPOUNDS, COMPOSITIONS AND METHODS |
2010 |
- Ren Pingda
- Liu Yi
- Wilson Troy Edward
- Li Liansheng
- Chan Katrina
- Rommel Christian
|
RU2746319C2 |
| MORPHOLINO-SUBSTITUTED DERIVATIVES OF UREA OR CARBAMATE AS MTOR INHIBITORS |
2012 |
- Lynch Rosemary
- Cansfield Andrew David
- Hardy Daniel Paul
- Sunose Mihiro
- Morel Adeline
- Convery Laura
- Adrego Rita
|
RU2616619C2 |
| HYDROXYLATED PYRIMIDYLCYCLOPENTANES AS PROTEIN KINASE (AKT) INHIBITORS |
2009 |
- Benksik Jozef R.
- Blehjk Dzhejms F.
- Kallan Nikolas K.
- Mitchell Jan S.
- Spenser Kit Li
- Ksiao Dengming
- Ksu Rui
- Chabot Kristin
- Do Stiven
- Liang Dzun
- Safina Brajan
- Chzhang Birong
|
RU2504542C2 |
| COMPOSITIONS, CONTAINING (S)-2-AMINO-1-(4-CHLOROPHENYL)-1-[4-(1H-PYRAZOL-4-YL)PHENYL]ETHANOL AS MODULATORS OF PROTEINKINASES |
2008 |
- Stiven Dzhon Vudkhed
- Dejvid Charlz Ris
- Martin Frederikson
- Kajla Merriom Grimsho
|
RU2527151C2 |
| TREATING NEUROENDOCRINE TUMOURS |
2006 |
- Marks Piter Uehjn
- Lebuol' Dejvid
|
RU2487711C2 |
| COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS |
2006 |
- Rehn' Pinda
- Grej Natanaehl S.
- Van Sja
- Chzhan Guobao
|
RU2383545C2 |
