BICYCLIC HETEROCYCLIC SPIROCOMPOUNDS Russian patent published in 2014 - IPC C07D491/107 C07D491/20 C07D495/10 C07D498/10 C07D513/10 A61K31/438 A61P3/04 A61P3/10 A61P25/28 

FIELD: chemistry.

SUBSTANCE: invention relates to compounds of general formula I where A is such as given in the invention formula, R is selected from the group consisting of H and C_1-6 alkyl, n and p each is independently selected from 0, 1 and 2, on condition that n + p = 2; Y represents -O- or -S-; R¹, R², R³, R⁴ in each position are independently selected from H and C_1-6 alkyl; R⁵ is selected from the group consisting of -C(O)-CH₂-indol-3-yl, -C(O)-(CH₂)₂-indol-3-yl, -C(O)-(CH₂)₃-indol-3-yl, trans -C(O)-(CH=CH)-indol-3-yl, -SO₂-4-fluorophenyl, -C(O)-CH(n-propyl)₂, -C(O)-(4-hydroxy-3,5-di-tert-butylphenyl), -C(O)-CH(NH₂)-CH₂-indol-3-yl and -C(O)-CH₂CH₃; and R⁶ represents H. Invention also relates to pharmaceutical composition for modulation of muscarinic receptor M1, containing formula I compounds, and methods of treating disease or state, curable by modulator of muscarinic receptor M1.

EFFECT: formula I compounds as modulators of muscarinic receptor M1.

33 cl, 1 tbl, 27 ex