DIAZASPIROPIPERIDINE DERIVATIVES AS GLYCINE CARRIER 1 AND GLYCINE CARRIER 2 INHIBITORS Russian patent published in 2009 - IPC C07D471/10 A61K31/435 A61P25/00 

FIELD: chemistry.

SUBSTANCE: invention refers to new compounds of general formula where A-B stands for CH₂-CH₂, -CH₂-O-, -O-CH₂-, -CH₂-S-, -S-CH₂-, -N(R⁴)-CH₂- or -CH₂-N(R⁴)-; R¹ stands for (lower)alkyl, (lower)alkenyl, cycloalkyl or stands for aryl, optionally substituted with one or two substitutes chosen from the group consisting of haloid, cyano, (lower)alkyl, CF₃, OCF₃ or (lower)alkoxy, or stands for heteroaryl representing cyclic aromatic hydrocarbon radical containing one or two heteroatoms chosen of the group consisting of sulphur or nitrogen, e.g. thiazolyl or thienyl, optionally substituted with one or two substitutes chosen from (lower)alkyl; R² stands for (lower)alkyl, cycloalkyl or stands for aryl, optionally substituted with one or two substitutes chosen from the group consisting of haloid, (lower)alkyl, CF₃, (lower)alkoxy, or stands for heteroaryl representing cyclic aromatic hydrocarbon radical containing one sulphur heteroatom, e.g. thienyl; R³ stands for hydrogen; R⁴ stands for hydrogen or benzyl; n stands for 0, 1 or 2; and to their pharmaceutically acceptable salts. Besides, the invention concerns a medical product.

EFFECT: production of new biologically active compounds inhibiting glycine carrier 1 (GlyT-1).

19 cl, 59 ex, 1 tbl