FIELD: biotechnologies.
SUBSTANCE: invention refers to genetically modified bacteria Salmonella enterica, which contain at least one operon pgI from Campylobacter jejuni or its functional derivative and refers to presentation of at least one N-glycan from Campylobacter jejuni or derivative of this N-glycan on their cell surface. In bacteria one or several genes for biosynthesis of bacillozamine are inactivated by mutation and/or partial or complete deletion of genes pgID, E, F, G. Invention provides method for obtainment of genetically modified bacteria Salmonella enterica. Invention is directed to application of modified bacteria in pharmacological compositions of medical and veterinary purpose and methods for treatment and/or prevention of infections Campylobacter and, not obligatory, Salmonella.
EFFECT: invention provides safety and efficiency of treatment and prevention of infections, which affect people and animals, namely livestock and fowl.
18 cl, 4 dwg, 1 tbl, 6 ex
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| SALMONELLA VACCINE | 2007 |
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|
RU2683027C2 |
| VACCINES AGAINST SALMONELLA CAUSING CROSS-IMMUNITY | 2013 |
|
RU2679039C2 |
| IMPROVED Bordetella pertussis VACCINES BASED ON MUTANT GLYCOSYLTRANSFERASES LPS | 2008 |
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RU2542667C2 |
| METHOD OF PRODUCING SIALYLATED OLIGOSACCHARIDES | 2007 |
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| INDUCTION OF PROTECTIVE IMMUNITY AGAINST ANTIGENS | 2018 |
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RU2723031C2 |
| COMPOSITIONS CONTAINING BACILLAENE-PRODUCING BACTERIA OR PREPARATIONS THEREOF | 2020 |
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| POLYVALENT INACTIVATED VACCINE AGAINST RIEMERELLOSIS, PASTEURELLOSIS AND SALMONELLOSIS OF TURKEYS, DUCKS AND GEESE, THE METHOD OF ITS PREPARATION | 2020 |
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RU2750865C1 |
