METHOD OF PRODUCING ARTIFICIAL OLIGONUCLEOTIDES POTENTIALLY CAPABLE OF FORMING IMPERFECT G-QUADRUPLEXES Russian patent published in 2014 - IPC C12N15/00 C12N15/10 G06F19/22 

FIELD: chemistry.

SUBSTANCE: invention relates to biotechnology, specifically a method of producing artificial oligonucleotides that are potentially capable of forming non-canonical structures that stable in physiological conditions and conditions close to physiological, said structures being imperfect G-quadruplexes (lmGQ) which include one nucleotide substitution in the G₄ plane in the G-quadruplexes (GQ). Said method includes using an algorithm describing nucleotide sequences in form of a defined set of formulae for further synthesis of selected oligonucleotides.

EFFECT: invention enables to use bioinformation analysis to obtain artificial oligonucleotides that are potentially capable of forming a new conformation - imperfect G-quadruplexes.

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