METHOD FOR PREPARING BONE MINERAL COMPONENT, AND BONE MINERAL COMPONENT FOR FILLING AND REPLACING BONE DEFECTS Russian patent published in 2014 - IPC A61K35/32 A61P19/10 

FIELD: medicine.

SUBSTANCE: what is described is a method for preparing a bone mineral component consisting in the fact that a bone spongy tissue is sawn up to bricks of 0.008 to 0.125 cm³, that are immersed into 2% sodium chloride that is followed by salting out of proteins, blood corpuscles and fat particles from bone spongy tissue trabecular for 24÷48 hours; the bricks are flushed with water; hydrolysis is performed in 2% sodium hydroxide for 24÷48 hours; the hydrolyzate is poured out, while the bricks are flushed with water while stirring continuously to neutralise sodium hydroxide completely; the bricks are immersed into 3-4% hydrogen peroxide for 10÷16 hours; the bricks are flushed with water; the bricks are degreased for 48 to 72 hours in mixed chloroform and ethanol taken in 2:1; the bricks are flushed in distilled water while stirring continuously, then heated, increasing temperature from 600 to 1200°C gradually, and additionally heated to 1200÷1300°C for 2-5 minutes.

EFFECT: preparing the bone mineral component with the manifested osteoconductive effect.

6 cl, 2 ex