HUMAN ANTIBODIES WITH HIGH AFFINITY TO HUMAN NERVE GROWTH FACTOR Russian patent published in 2013 - IPC C07K16/22 C12N15/13 C12N15/63 A61K39/395 A61P43/00 

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention discloses a human antibody or an antigen-binding antibody fragment which specifically binds human nerve growth factor (NGF) with K_D in the order of 5 pM or less and does not cross-react with neurotrophin-3 (NT-3). The antibodies are effective in treating inflammatory pain, postoperative suture pain, neuropathic pain, fracture pain, osteoporotic fracture pain, postherpetic neuralgia, pain associated with osteoarthritis, rheumatoid arthritis, cancer, burns, joint pain in gout, as well as such diseases as hepatocellular carcinoma, breast cancer and hepatic cirrhosis. The invention discloses a nucleic acid coding a human antibody or its antibody-binding fragment, an expression vector containing the nucleic acid, and a method for producing the antibody or its antigen-binding fragment. The antibody or its fragment is used to create a pharmaceutical composition for treating the above diseases, as well as a drug preparation additionally containing IL-1 inhibitor, an antiepileptic drug, a cytokine antagonist and another neurotrophin.

EFFECT: specificity of human NGF binding by the antibody or its fragment according to the invention is 2-10 times higher than a binding ability of the antibody or its fragment in relation to rat's or mouse's NGF.

21 cl, 28 tbl, 13 ex