5-OXYPYRIMIDINE DERIVATIVE POSSESSING ANTINEOPLASTIC ACTIVITY Russian patent published in 2014 - IPC C07D239/34 A61K31/505 A61P35/00 A61P37/02 

Abstract RU 2518889 C2

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to a new antineoplastic drug representing 2-isobutyl-4,6-dimethyl-5-oxypyrimidine of the general formula I specified below. The drug may be used for an adjuvant antineoplastic immune therapy. The invention also refers to a method for preparing 2-isobutyl-4,6-dimethyl-5-oxypyrimidine. According to the method, isocaproic acid amide reacts in ice-cold acetic acid with chloracetyl acetone to form the respective oxazole which reacts with aqueous ammonia which leads to preparation of the above compound.

EFFECT: what is disclosed is a manifested tumour growth inhibition with no signs of the toxic effect on somatic characteristics of tumour-carrier mice.

3 cl, 9 tbl, 6 ex

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RU 2 518 889 C2

Authors

Seredenin Sergej Borisovich

Nikitin Sergej Vasil'Evich

Kovalenko Larisa Petrovna

Durnev Andrej Dmitrievich

Dates

2014-06-10Published

2011-03-01Filed