LIGANDS FOR AGGREGATED MOLECULES OF TAU-PROTEIN Russian patent published in 2014 - IPC C07D277/66 C07D417/12 C07D471/04 C07D487/04 C07D513/04 G01N33/58 G01N33/68 A61K49/00 A61K51/00 

FIELD: chemistry.

SUBSTANCE: invention relates to method of labelling paired helical filaments (PHF), which includes interaction of PHF with compound and detection of said compound presence, where compound has formula , in which -R- stands for , -Q- is selected from: -NHC(O)-, -N=N-, -CH=CH-; -P is selected from: ; -T is selected from: ; X represents N or CH; -W^1-6, -G^1-4, -P^1-5 are such as given in the invention formula. Invention also relates to method of labelling aggregated tau-protein, which includes interaction of aggregated molecules of tau-protein with compounds and detection of said compound presence, and to compounds of formula , in which values of substituents are such as given in the invention formula.

EFFECT: formula compounds as labels of tau-protein and paired helical filaments (PHF).

28 cl, 5 dwg, 225 ex