ANTIFIBROUS PYRIDINONES Russian patent published in 2019 - IPC C07D471/04 C07D401/04 C07D405/04 C07D413/04 C07D417/04 C07D491/04 C07D495/04 C07D209/00 C07D211/00 C07D213/00 A61K31/4375 A61K31/4985 A61P11/00 

FIELD: chemistry.

SUBSTANCE: invention relates to compounds of structural formula (III)

or pharmaceutically acceptable salts thereof, where R¹ is selected from a group consisting of 5–9-member heteroaryl having 1 to 3 heteroatoms selected from S, O and N, and optionally substituted with one or more R⁴; R³ is selected from a group consisting of C_6-10aryl optionally substituted with one or more R⁹; ring A is selected from a group consisting of 5–6-member heteroaryl having from 1 to 3 heteroatoms selected from S, O and N, optionally substituted with one or more R⁴; Z is selected from oxygen and sulfur; each n independently represents integer from 0 to 4; and bonds, represented by solid and dashed lines, are independently selected from a group consisting of a single bond and a double bond, provided that at least one of hydrogen atoms R¹ or R³ is deuterium; other values of radicals are presented in cl. 1.

EFFECT: declared compounds are used to prevent or diagnose diseases, disorders or conditions associated with fibrosis.

32 cl, 3 tbl, 31 ex