TOOTHPASTE COMPOSITION Russian patent published in 2014 - IPC A61K8/27 A61K8/365 A61K8/72 A61Q11/00 

FIELD: medicine, pharmaceutics.

SUBSTANCE: group of inventions concerns a toothpaste composition containing a metal ion source, and a method for stabilising the above metal ion source in the composition. What is disclosed is the toothpaste composition containing an orally acceptable base, and at least one metal ion source in a polymer matrix with the metal ion source containing at least one of zinc citrate, zinc lactate, zinc gluconate, zinc oxide, tin chloride, tin fluoride, tin oxide or copper sulphate or combinations thereof. The composition contains at least one of zinc oxide and zinc citrate in the polymer matrix. The amount of the metal ion source makes 20 to 60 wt % of the total weight of the polymer matrix and the above metal ion source; the amount of the polymer matrix and the metal ion source is 1 to 5 wt % of the total weight of the toothpaste composition. The polymer matrix represents a water-hydratable film having a matrix consisting of a water-soluble hydroxyalkyl cellulose polymer having the mucoadhesive properties. The toothpaste composition contains at least 10 wt % of water of the total weight of the composition. The base of the composition contains zinc citrate, and at least one phosphate specified in at least one of sodium hexametaphosphate, sodium tripolyphosphate and tetrasodium polyphosphate. The method for stabilising the above metal ion source in the toothpaste composition is implemented by including the above metal ion source into the above polymer matrix and combining the prepared polymer matrix with the orally acceptable base containing zinc citrate and at least one of the above phosphate compounds with water content less than 10 wt % of the total weight of the composition.

EFFECT: presented composition and method provide stabilising the metal ion source if the phosphate compound and zinc citrate is found in the base of the composition.

10 cl, 3 tbl, 3 ex