METHOD FOR PREPARING BIOADHESIVE COMPACTED MATRIXES WHICH MAY BE USED AS SUCH OR FOR PROLONGED RELEASE OF ACTIVE SUBSTANCES, AND COMPACTED MATRIXES PREPARED BY THIS METHOD Russian patent published in 2014 - IPC A61K9/20 A61K9/22 A61K31/55 A61K31/64 

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to medicine. What is described is a method for preparing a bioadhesive compacted matrix that involves preparing a homogenous mixture of powders containing at least one alkyl cellulose or one hydroxyalkyl and a water-insoluble, water-swelling cross-linked polycarboxyl polymer, using the same powder mixture to prepare compressed work pieces using direct extrusion and heating of the compressed work pieces prepared thereby to the temperatures within the range of 80-250°C for 1-60 minutes. The powder mixture may also contain at least one active substance.

EFFECT: compressed work pieces prepared thereby are characterised by the prolonged release and show the kinetics of the active substance release of substantially zero order in an aqueous solution at pH 4-8.

15 cl, 18 dwg, 5 tbl, 4 ex