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2 481 336

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IPC

C07D239/70(2006-01-01)

C07D401/12(2006-01-01)

C07D401/14(2006-01-01)

C07D403/12(2006-01-01)

C07D403/14(2006-01-01)

C07D405/12(2006-01-01)

C07D405/14(2006-01-01)

C07D409/12(2006-01-01)

C07D409/14(2006-01-01)

A61K31/517(2006-01-01)

A61P35/00(2006-01-01)

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Application

2009103899/04, 2007-07-05

(24)

Start date

2007-07-05

(22)

Actual filing date

2007-07-05

(45)

Published

2013-05-10

(72)

Inventor

Mitchel Jan S.Blehjk Dzhejms F.Ksu RuiKallan Nikolas K.Ksiao DengmingSpenser Kit LiBenksik Jozef R.Liang DzunSafina BrajanLi TszunChabot KristinUolles Ilaj M.Banka Anna L.Shlekhter Stiven T.

(73)

Holder

Ehrrehj Biofarma Ink.Dzhenentek, Ink.

CYCLOPENTA(D)PYRIMIDINES AS PROTEIN KINASE AKT INHIBITORS Russian patent published in 2013 - IPC C07D239/70 C07D401/12 C07D401/14 C07D403/12 C07D403/14 C07D405/12 C07D405/14 C07D409/12 C07D409/14 A61K31/517 A61P35/00

Abstract RU 2481336 C2

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to compounds of formula I , as well as to enantiomers and salts thereof, wherein R¹ and R^1a are independently specified in H, Me, Et, CH=CH₂, CH₂OH, CF₃, CHF₂ or CH₂F; R² and R^2a are independently specified in H or F; R⁵ represents H, Me, Et or CF₃; A is presented by formula: ; wherein G, R⁶, R⁷, R^a, R^b ,R^c, R^d, R⁸, m, n and p are presented in cl. 1 of the patent claim.

EFFECT: compounds according to the invention may be used as the protein kinase Akt inhibitors and for treating hyperproliferative diseases, such as cancer.

15 cl, 1 tbl, 43 ex

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RU 2 481 336 C2

Authors

Mitchel Jan S.

Blehjk Dzhejms F.

Ksu Rui

Kallan Nikolas K.

Ksiao Dengming

Spenser Kit Li

Benksik Jozef R.

Liang Dzun

Safina Brajan

Li Tszun

Chabot Kristin

Uolles Ilaj M.

Banka Anna L.

Shlekhter Stiven T.

Dates

2013-05-10—Published

2007-07-05—Filed