METHOD FOR CORRECTION OF OXIDATIVE STRESS AND NO PRODUCING ENDOTHELIAL DYSFUNCTION ACCOMPANYING VASCULAR COMPLICATIONS OF DIABETES MELLITUS IN EXPERIMENT Russian patent published in 2014 - IPC A61K31/00 A61K31/415 A61P9/00 A61P39/06 A61P43/00 

FIELD: medicine.

SUBSTANCE: method involves preliminary intraperitoneal single administration of 5% aqueous alloxan in a dose of 15 mg/kg of body weight into a rat's body on an empty stomach. That is followed by administering afobazol under conditions of oxidative stress after observing the rat's blood glucose gain at least twice. Afobazol is administered subcutaneously in a dose of 10 mg/kg of body weight once a day for 30 days with underlying administration of L-arginine in a dose of 10 mg/kg of body weight or with underlying NG-nitroarginine methyl ester (L-NAME)-inhibitor of NOS-3 enzyme in a dose of 25 mg/kg of animal's weight.

EFFECT: method enables correcting the oxidative stress and NO-producing endothelial dysfunction accompanying vascular complications of diabetes mellitus.

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