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IPC

G09B23/08(2006-01-01)

A61K31/05(2006-01-01)

A61P15/06(2006-01-01)

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Application

2010121673/14, 2010-05-27

(24)

Start date

2010-05-27

(22)

Actual filing date

2010-05-27

(45)

Published

2011-10-27

(72)

Inventor

Pokrovskij Mikhail VladimirovichGureev Vladimir VladimirovichBarsuk Anna AleksandrovnaProskurjakova Elena Vital'EvnaLazareva Galina Anatol'EvnaPokrovskaja Tat'Jana Grigor'EvnaPoljanskaja Oksana SergeevnaGureeva Elena GennadievnaKorokin Mikhail ViktorovichGudyrev Oleg SergeevichBelous Aleksandr SergeevichTsybul'Skij Igor' Valer'EvichDanilenko Ljudmila MikhajlovnaKochkarov Vladimir IskhakovichNovikov Oleg Olegovich

(73)

Holder

Gosudarstvennoe Obrazovatel'Noe Uchrezhdenie Vysshego Professional'Nogo Obrazovanija Gosudarstvennyj Meditsinskij Universitet Federal'Nogo Agentstva Po Zdravookhraneniju I Sotsial'Nomu Razvitiju"

METHOD FOR PLACENTAL MICROCIRCULATION DISORDER CORRECTION IN ADMA-LIKE GESTOSIS MODELS IN EXPERIMENT Russian patent published in 2011 - IPC G09B23/08 A61K31/05 A61P15/06

Abstract RU 2432618 C1

FIELD: medicine.

SUBSTANCE: methods for endothelial dysfunction correction are developed by simulating of an ADMA-like gestosis model in pregnant laboratory pregnant Wistar rats by intraperitoneal introduction of L-nitro-arginin methyl ester 25 mg/kg for 7 days. For endothelial dysfunction correction, such simulation is combined with intragastric introduction resveratrol 2 mg/kg once a day for 7 days.

EFFECT: method provides expressed placental microcirculation disorder correction in the condition of radical change of an endocrine profile and regulatory mechanism relationships during pregnancy due to an integrated effect of resveratrol exhibiting certain estrogenic activity and antioxidant properties.

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RU 2 432 618 C1

Authors

Pokrovskij Mikhail Vladimirovich

Gureev Vladimir Vladimirovich

Barsuk Anna Aleksandrovna

Proskurjakova Elena Vital'Evna

Lazareva Galina Anatol'Evna

Pokrovskaja Tat'Jana Grigor'Evna

Poljanskaja Oksana Sergeevna

Gureeva Elena Gennadievna

Korokin Mikhail Viktorovich

Gudyrev Oleg Sergeevich

Belous Aleksandr Sergeevich

Tsybul'Skij Igor' Valer'Evich

Danilenko Ljudmila Mikhajlovna

Kochkarov Vladimir Iskhakovich

Novikov Oleg Olegovich

Dates

2011-10-27—Published

2010-05-27—Filed