DIAGNOSTIC TECHNIQUE FOR CLINICALLY LATENT HYPERCORTICOIDISM IN PATIENTS SUFFERING FROM STYPE 2 DIABETES MELLITUS OR OBESITY Russian patent published in 2014 - IPC G01N33/74 

FIELD: medicine.

SUBSTANCE: first stage comprises a night suppressive test with dexamethasone 1 mg with a test considered to be positive, if plasma cortisol measured at 8.00 in the next morning exceeds 50 nmole/l. If the first stage has a positive result, the second stage is performed 1-2 days later. At the second stage, blood plasma cortisol at 24.00, daily urine free cortisol, a coefficient of circadian rhythm of cortisol secretion are determined on the same day. If at least two of the three test results are above normal: plasma cortisol at 24.00 is more than 207 nmole/l, daily urine free cortisol is more than 180 mcg/day, coefficient of circadian rhythm of cortisol secretion is more than 50%, hypercorticoidism syndrome is diagnosed. The presented technique provides higher accuracy and simplifies diagnosing of the given disease.

EFFECT: technique enables well-timed adequate therapeutic approach, prevents the disease transformation into manifestative hypercorticoidism with developing severe disabling complications.

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