METHOD OF EVALUATING SAFETY OF USE OF SYSTEMIC CORTICOSTEROIDS Russian patent published in 2016 - IPC G01N33/74 

FIELD: medicine.

SUBSTANCE: invention can be used for evaluating safety of use of systemic corticosteroids. Method involves determination of cortisol concentration in blood and saliva before and after treatment, the assessment is carried out taking into account the physiological peak of cortisol secretion by adrenal gland cortex. Free cortisol fraction levels are compared, recorded in saliva, and associated fraction of hormone, determined in blood. Data recorded in the dynamics: before treatment, on the eighth day of treatment, three days and three months after treatment, and material is sampled during hours when cortisol secretion in humans is maximized. Using the invention provides higher accuracy of corticosteroid dosing based on analysis of secretion of free and bound fractions in the adrenal gland cortex, carried out with account of daily rate of circulation of this hormone.

EFFECT: invention enables the timely correction of treatment and avoiding adverse effects.

2 cl, 2 ex, 4 dwg