METHOD FOR REGIOSELECTIVE SYNTHESIS OF MONOHALOGEN DERIVATIVES OF 1,2-, 1,7-, 1,12-DICARBA-CLOSO-DODECABORANES(12) Russian patent published in 2014 - IPC C07F5/02 

FIELD: chemistry.

SUBSTANCE: invention relates to the technology of producing organoboron compounds, particularly a method for regioselective synthesis of monohalogen derivatives of 1,2-, 1,7-, 1,12-dicarba-closo-dodecaboranes(12). The method involves reacting o(m,p)-carboranes with halogenating agents in a medium of an acidic organic solvent, followed by extraction of the end product. The process is carried out in the presence of a catalyst in the form of a strong acid: sulphuric acid (H₂SO₄), methanesulphonic acid (CH₃SO₂OH) and trifluoro-methanesulphonic acid (CF₃SO₂OH) in amount of 0.1-1.0 mol%. The process is carried out at boiling point of the acidic organic solvent for 2-5 hours, wherein the acidic organic solvent used is monobasic liquid organic acids of the aliphatic series R-COOH, where R=H, C_nH_2n+1, C_nF_2n+1, n=1-3, with a linear and branched structure. The halogenating agents used are N-haloimides(amides): N-halosuccinimides, 1,3-dihalo-5,5-dimethyl hydantoins, trihaloisocyanuric acids, N-haloarylsulphonamides and sodium salts thereof, N-halophthalimides, where the halogen is Cl, Br, I; aryl is phenyl, p-tolyl.

EFFECT: invention simplifies synthesis of said compounds, increases efficiency of the process and reduces power consumption.

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