SINGLE-CHAIN ANTIBODY TO CARCINOEMBRYONIC ANTIGEN, CHIMERIC MONOMOLECULAR T-CELL RECEPTOR, VECTOR AND HOST CELL FOR PROVISION OF SUCH RECEPTOR AND METHOD OF DIAGNOSTICS OR TREATMENT Russian patent published in 2014 - IPC C07K16/46 C12N15/63 C12N5/10 A61K39/395 

FIELD: medicine.

SUBSTANCE: inventions relate to the field of immunology. Claimed are a single-chain antibody, specific to a carcinoembryonic antigen, a chimeric mononuclear T-cell receptor, a vector, a host cell and a method of diagnostics or treatment of diseases, characterised by the presence of antigens, capable of binding with the chimeric receptor. Described is a genetic construction, coding chimeric monomolecular T-cell receptors, in which an effector fragment of the T-cell receptor is combined with an antigen-recognising part, which represents variable fragments of two different antibodies to the carcinoembryonic antigen (CEA).

EFFECT: claimed inventions can be used in T-cell cancer therapy.

7 cl, 4 dwg, 3 ex, 1 tbl