FIELD: medicine.
SUBSTANCE: invention relates to biotechnology, specifically to the production of a lentiviral vector for the expression of a chimeric antigenic receptor (CAR) based on a CD47 VHH antibody in human T-cells, and can be used in medicine.
EFFECT: obtained target T-cells presenting CAR to CD47 are characterized by high level of CAR expression, low immunogenicity and increased circulation time in the body and can be used for effective immunotherapy of malignant growths.
1 cl, 3 dwg, 3 ex
| Title |
Year |
Author |
Number |
| RECOMBINANT STRAIN OF HERPESVIRUS SAIMIRI FOR OBTAINING POPULATIONS OF IMMORTALISED AUTOLOGOUS T LYMPHOCYTES EXPRESSING PAIRED CHIMERIC RECEPTORS AGAINST CD44 AND CD133 TUMOUR ANTIGENS |
2020 |
- Chumakov Stepan Petrovich
- Kravchenko Iuliia Evgenevna
- Kravchenko Dmitrii Sergeevich
- Frolova Elena Ivanovna
|
RU2771081C2 |
| CHIMERIC ANTIGENIC RECEPTORS WITH MND-PROMOTER |
2015 |
- Morgan, Richard
- Friedman, Kevin
- Ryu, Byoung
|
RU2708311C2 |
| CHIMERIC ANTIGENIC RECEPTORS WITH MND PROMOTER |
2015 |
- Morgan, Richard
- Friedman, Kevin
- Ryu, Byoung
|
RU2799573C2 |
| NK CELL LINE EXPRESSING PSMA-SPECIFIC CHIMERIC ANTIGEN RECEPTOR AND SECRETING CD47/SIRPA INTERACTION BLOCKER |
2020 |
- Gorchakov Andrej Aleksandrovich
- Kulemzin Sergej Viktorovich
- Chikaev Anton Nikolaevich
- Taranin Aleksandr Vladimirovich
|
RU2757353C1 |
| METHOD FOR PRODUCING MODEL IMMORTALIZED CELL LINE CONTAINING RECONSTRUCTED B-CELL RECEPTOR OF NON-HODGKIN LYMPHOMAS |
2018 |
- Stepanov Aleksej Vyacheslavovich
- Ukrainskaya Valeriya Mikhajlovna
- Belogurov Aleksej Anatolevich
- Gabibov Aleksandr Gabibovich
|
RU2720912C1 |
| MULTI-CHAIN CHIMERIC ANTIGEN RECEPTOR AND USES THEREOF |
2013 |
- Smit Dzhulianna
- Sharenberg Endryu
- Manniui Sesil
- Ekem Zhyusten
|
RU2663725C2 |
| CD19-SPECIFIC CHIMERIC ANTIGEN RECEPTOR AND USE THEREOF |
2014 |
- Galetto Roman
- Smit Dzhulianne
- Sharenberg Endryu
- Shiffer-Manniui Sesil
|
RU2727447C2 |
| LABELED CHIMERIC EFFECTOR MOLECULES AND RECEPTORS THEREOF |
2014 |
- Riddell, Stanley, R.
- Liu, Lingfeng
|
RU2729463C2 |
| CD33-SPECIFIC CHIMERIC ANTIGENIC RECEPTORS FOR CANCER IMMUNOTHERAPY |
2015 |
|
RU2701341C2 |
| PHARMACEUTICAL COMPOSITION POSSESSING ANTITUMOUR EFFECT, AND METHOD FOR REDUCING PD-L1 INHIBITING EFFECT ON HUMAN T-CELLS |
2016 |
|
RU2688692C2 |
