METHOD FOR PREDICTION OF AGGRAVATED BRONCHIAL ASTHMA AND/OR CYSTIC FIBROSIS ACCOMPANYING INFLUENZA IN CHILDREN Russian patent published in 2014 - IPC G01N33/53 

FIELD: medicine.

SUBSTANCE: prognostic indices resulted from calculated interleukins IL-4, IL-10 and interferon gamma IFN-y in blood serum are determined by enzyme immunoassay on the first and third day of the disease. An increase of interleukin IL-4, IL-10 and a decrease of IFN-γ over time with an increase of the relations of IL-4/IFN-γ by the third day at least in 5-6 times, and of IL-10/IFN-γ at least in 4-5 times, influenza can be considered as a trigger of aggravated chronic bronchopulmonary pathology - bronchial asthma and cystic fibrosis. The derived coefficients determine an algorithm of early application of combined therapeutic schemes of influenza in the children with chronic non-specific pulmonary diseases with using antiviral, antibacterial and immunocorrecting preparations for the purpose of eliminating cytokine imbalance and preventing virus-induced bronchial obstruction as a result of less hyperactive tracheobronchial tree. A prognostic accuracy of the presented method makes 85-90%.

EFFECT: higher prediction accuracy.

4 tbl, 4 ex