METHOD FOR DIFFERENTIAL DIAGNOSIS OF CHRONIC RHINOSINUSITIS IN CHILDREN Russian patent published in 2024 - IPC G01N33/52 A61B5/00 

FIELD: medicine.

SUBSTANCE: invention refers to medicine, particularly to otorhinolaryngology, and can be used for differential diagnosis of chronic rhinosinusitis. At the diagnostic stage, nasal secretion is sampled, in which the levels of markers are determined by enzyme immunoassay IFN-γ, IL-33, IL-35, ECP, MPO, TGF-β1. At values in nasal secretion of level IFN-γ ranging from 1201.04 to 1221.76 pg/ml Th-1 endotype – chronic rhinosinusitis without polyps and comorbid pathology – is diagnosed. At value in nasal secretion of level of markers MPO ranging from 645.5 to 708.54 mcg/l, TGF-β1 ranging from 83.05 to 95.71 pg/ml, IL-35 ranging from 42.64 to 44.12 pg/ml endotype with pharyngeal lymphatic ring hypertrophy is diagnosed. At values in nasal secretion ECP ranging from 14.91 to 17.35 mcg/l, IL-33 ranging from 22.01 to 23.71 pg/ml Th-2 endotype – chronic rhinosinusitis with possible development of severe clinical course and comorbid pathology – is diagnosed. After that, venous blood is taken from the child with diagnosed Th-2 endotype, and the level of markers is determined in blood serum by immunoassay IL-17α, IL-22, IL-35, ECP. With values IL-17α ranging from 8.41 to 8.89 pg/ml, IL-22 ranging from 103.13 to 116.61 pg/ml sub-endotype is diagnosed – chronic rhinosinusitis with polyps. With values ECP ranging from 20.96 to 29.58 mcg/l sub-endotype is diagnosed – chronic rhinosinusitis with allergic rhinitis. With values IL-35 ranging from 1.48 to 4.88 pg/ml sub-endotype is diagnosed – chronic rhinosinusitis with bronchial asthma.

EFFECT: use of the method enables differential diagnosis of chronic rhinosinusitis in children by using objective assessment criteria, allowing clear, fast diagnosis of endotypes, sub-endotypes of chronic rhinosinusitis in children.

1 cl, 1 dwg, 4 tbl, 5 ex