METHOD FOR PREDICTION OF SEVERITY OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE Russian patent published in 2014 - IPC G01N33/50 

FIELD: medicine.

SUBSTANCE: invention refers to medicine, and aims at treating chronic obstructive pulmonary disease (COPD). When taking into account a quantity of courses of antibiotic administration for aggravated COPD during previous 12 months, a standard 6-minute walking test involves estimating a 6-minute distance, the heart rate prior to the walking test and oxygen saturation after the walking test; a biomaterial is sampled from the posterior wall of the pharynx by oropharyngeal smears to recover DNA and to sequence; observing proteobacteria involves recoding of the derived data into a qualitative variable; genome DNA is recovered from the COPD patients' blood that is followed by genetic typing by CD14 rs2569190 and IL18 rs1946518 genes; the genetic typing data are pre-recorded into digital values to calculate a discriminant function and to make a forecast.

EFFECT: presented method enables a higher accuracy, information value and sensitivity and enables predicting a severity of COPD effectively, as well as differentiating a severe and very severe clinical course of a moderate and mild COPD.

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