FIELD: biotechnology.
SUBSTANCE: method of production of antirabic vaccine for animals comprises preparing of inoculum from the strain of rabies virus, infection contamination with the inoculum of the culture of the continuous cells, culturing the rabies virus, collection of virus-containing suspension with its subsequent inactivation and preparation of the target product, at that the inactivation is carried out by adding the virus-containing suspension to ethanol in the final concentration of 18-20%, exposure for 20-22 hours at a temperature of 36-37°C under constant stirring, then 4-6% aluminium hydroxide is added in a ratio to the reaction mixture of 1:(4.5-5.0).
EFFECT: simplification of the method and improvement of quality of the product by increasing the shelf life of the target product.
2 ex
| Title | Year | Author | Number |
|---|---|---|---|
| ANTIRABIC VACCINE FOR ANIMALS ("УНИРЭВ") | 2008 |
|
RU2366457C1 |
| METHOD FOR OBTAINING ANTIRABIC VACCINE | 2001 |
|
RU2191600C1 |
| METHOD OF PRODUCTION OF ANTIRABIC VACCINE | 2013 |
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RU2538617C2 |
| METHOD FOR PREPARING ANTIRABIC VACCINE | 2005 |
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RU2287343C1 |
| METHOD FOR PREPARING INACTIVATED ANTIRABIC VACCINE IN FRAMELESS CELL GROWTH AND VIRUS REPLICATION IN SHORT-TERM CULTURE CYCLE | 2012 |
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RU2537183C2 |
| METHOD OF PRODUCING CULTURE INACTIVATED RABIES VIRUS VACCINE | 2023 |
|
RU2816765C1 |
| METHOD OF PREPARING ANTIRABIC INACTIVATED CULTURAL VACCINE | 1994 |
|
RU2077338C1 |
| VACCINE AGAINST PLAGUE, ADENOVIRUS INFECTIONS, PARVOVIRUS AND CORONAVIRUS ENTERITIS, LEPTOSPIROSIS AND RABIES OF DOGS | 2013 |
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| DRY RABIES VACCINE FOR CATTLE AND SMALL CATTLE | 2009 |
|
RU2402348C1 |
| ENA-21/13-13-FINITE MONOLAYER-SUSPENSION CELL SUBLINE OF KIDNEY OF NEW-BORN SYRIAN HAMSTER, INTENDED FOR REPRODUCTION OF FOOT-AND-MOUTH DISEASE VIRUS AND RABIES VIRUS | 2014 |
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