FIELD: biotechnology.
SUBSTANCE: invention relates to binuclear form of dinitrosyl iron complex with ethyl ether of glutathione (DNIC-EEG) of the formula [(EEGS)2Fe2(NO)4] with the structural formula: 
, where R-S represents ethyl ether of glutathione containing a thiol group. The invention also relates to a composition for reducing functional disorders of myocardium subjected to hypoxia-reoxygenation which contains binuclear form of dinitrosyl iron complex with ethyl ether of glutathione (DNIC EEG) as defined above and a pharmaceutically acceptable carrier. Also the use of DNIC-EEG is disclosed as antihypoxic agent.
EFFECT: reduction of hypoxic contracture, arrhythmias intensity and improvement of recovery of contractile function of the heart after reoxygenation.
3 cl, 1 tbl, 16 dwg, 4 ex
| Title | Year | Author | Number |
|---|---|---|---|
| METHOD FOR CELL PROTECTION AGAINST HYPOXIC INJURY BY GLUTATHIONYLATION OF Na, K-ADENOSINE TRIPHOSPHATASE CATALYTIC SUBUNIT | 2013 |
|
RU2544958C2 |
| APPLICATION OF BINUCLEAR SULPHUR-NITROSYL COMPLEX OF ANION TYPE IRON AS VASODEPRESSOR MEDICATION | 2010 |
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| USE OF BINUCLEAR SULPHUR-NITROSYL CATIONIC IRON COMPLEX AS VASODILATATOR | 2010 |
|
RU2460531C2 |
| DRUG FOR GLYCOGEN SYNTHESIS STIMULATION IN CARDIAC MUSCLE AND METHOD FOR GLYCOGEN SYNTHESIS STIMULATION IN CARDIAC MUSCLE | 2010 |
|
RU2438679C1 |
| METHOD OF ISOLATED HEART ISHEMIC AND REPERFUSION INJURIES PREVENTION | 2002 |
|
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| METHOD OF ERYTHROCYTES PROTECTION IN CARDIOSURGICAL PATIENTS OPERATED UNDER CONDITIONS OF ARTIFICIAL BLOOD CIRCULATION | 2019 |
|
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| GARCINOL AND CYCLODEXTRIN COMPLEX AND METHOD OF ITS APPLICATION | 2011 |
|
RU2566065C2 |
| ANTIHYPOXIA AGENT FOR EXPERIMENTAL STUDIES | 0 |
|
SU1461461A1 |
