METHOD FOR CELL PROTECTION AGAINST HYPOXIC INJURY BY GLUTATHIONYLATION OF Na, K-ADENOSINE TRIPHOSPHATASE CATALYTIC SUBUNIT Russian patent published in 2015 - IPC C12N5/00 A61P43/00 

Abstract RU 2544958 C2

FIELD: medicine.

SUBSTANCE: invention refers to methods for cell and tissue protection against a hypoxic injury and can be used for developing remedies for hypoxic and ischemic injuries. The developed method for protection is based on cell treatment by substances increasing a level of glutathionylation of Na,K-adenosine triphosphatase catalytic subunit that reduces to its activation. The obtained results can be actual for biological research institutions, medical facilities, particularly cardiologic clinics, as well as biotechnological companies for transplantology and tissue engineering.

EFFECT: presented method can be used for research activities aiming at creating the therapeutic agents for relieving tissue injuries, particularly myocardial tissue in hypoxia and hypoxia/reoxygenation.

6 dwg

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RU 2 544 958 C2

Authors

Makarov Aleksandr Aleksandrovich

Petrushanko Irina Jur'Evna

Mit'Kevich Vladimir Aleksandrovich

Burnysheva Ksenija Mikhajlovna

Simonenko Ol'Ga Vasil'Evna

Lopina Ol'Ga Dmitrievna

Klimanova Elizaveta Andreevna

Dergousova Elena Aleksandrovna

Dates

2015-03-20Published

2013-06-11Filed