HYALURONIC ACID DERIVATIVE, METHOD OF OBTAINING AND MODIFICATION THEREOF Russian patent published in 2015 - IPC C08B37/00 

FIELD: chemistry.

SUBSTANCE: invention relates to methods of obtaining and modification of a hyaluronan derivative, containing an aldehyde group in position (6) of a glucosamine polysaccharide fragment. Claimed is a hyaluronic acid derivative. The derivative is oxidised by position 6 of the glucosamine fragment to the aldehyde (formula X)

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Its hydrated form is called geminal diol (formula Y)

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A method of obtaining the said hyaluronic acid derivative includes the interaction of hyaluronic acid with Dess-Martin periodinane (DMP) in a polar aprotic solvent. As the polar aprotic solvent, dimethylsulphoxide is preferably used. A method of modification of the obtained hyaluronic acid derivative is also claimed. The oxidised hyaluronic acid derivative is subjected to interaction with an amine of the general formula H₂N-R or with hyaluronan, substituted with the group -R-NH₂, where R is an alkyl with a linear or branched C₁-C₃₀ chain and optionally contains aromatic and heteroaromatic groups.

EFFECT: invention makes it possible to obtain the hyaluronic acid derivative with different possibilities of further modification due to the aldehyde group.

16 cl, 14 ex