FIELD: medicine.
SUBSTANCE: disclosed is microsphere formulation risperidone with sustained release comprising risperidone or 9-hydroxy risperidone or a salt thereof and a polymer blend comprising a first non-terminated lactide-glycolide copolymer and a second non-terminated lactide-glycolide copolymer, wherein first non-terminated lactide-glycolide copolymer is a copolymer with high internal viscosity (limiting viscosity number), and second non-terminated lactide-glycolide copolymer is a copolymer with low internal viscosity.
EFFECT: sustained release microsphere formulation is suitable for large-scale industrialised production with improved stability, formulation release in vivo will not change after prolonged storage.
18 cl, 9 dwg, 2 tbl, 14 ex
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