MANGANESE CHALATES AND USE THEREOF AS CONTRAST AGENTS IN MAGNETIC RESONANCE IMAGING (MRI) Russian patent published in 2015 - IPC A61K49/12 A61K49/10 C07D471/08 C07D471/04 

Abstract RU 2561718 C2

FIELD: chemistry.

SUBSTANCE: invention relates to compounds of formula (I)

wherein X is C1-C6alkyl; Y is C1-C6alkyl or -H; R is C1-C6alkyl, -N(C1-C6alkyl)2, -O(C1-C6alkyl), -NMe2, -NH2, -OMe, -OH or -H; Z is Mn(II) or -H, provided that if Z is Mn(II), then two Z-containing X groups have one common Mn(II). The invention also relates to a composition for use as a MR contrast medium for MRI, which contains the disclosed compound, a MRI method and use of the disclosed compound to prepare a diagnostic agent for use as a MR contrast medium.

EFFECT: obtaining manganese (II) based chalates which can be used as MRI contrast agents.

10 cl, 6 ex

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RU 2 561 718 C2

Authors

Meijer Andreas

Dates

2015-09-10Published

2010-12-17Filed