FIELD: chemistry.
SUBSTANCE: present invention relates to a method for producing an antibody or a binding fragment thereof, conjugated with a payload, comprising conjugating a compound of formula (I) with an antibody or a binding fragment thereof, containing at least one thiol group. Method employs mild conditions that provide molecules which are stable after production and are therefore suitable for administration in vivo.
EFFECT: method is proposed for conjugation of polypeptide.
21 cl, 40 dwg, 31 tbl, 53 ex
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