NEW HETEROARENANTHRACENE-2-CARBOXAMIDE DERIVATIVES INHIBITING TUMOUR GROWTH Russian patent published in 2017 - IPC C07D209/56 C07D307/77 C07D333/50 C07D405/06 C07D405/12 C07D409/06 A61K31/343 A61K31/403 A61K31/381 A61P35/00 

FIELD: pharmacology.

SUBSTANCE: invention relates to derivatives of linear heteroarenanthracenediones containing a substituted carboxamide group in position 2 corresponding to the formula below as well as their tautomeric forms and pharmaceutically acceptable salts, wherein X is independently a heteroatom selected from O, S or NH-group; Y is independently a diamine residue with one nitrogen atoms directly bonded to the carbonyl group at position 2 of the heterocyclic heteroarenanthracenedione nucleus selected from the group of diaminoalkanes, cyclic diamines, amino derivatives of cyclic amines optionally substituted by one or more substituents on nitrogen or carbon atoms. Optionally substituted diamine is independently selected from the group consisting of piperazine, spiropiperazine, 1,4-diazepine, 2,5-diazabicyclo[2.2.1]heptane, 4-aminopiperidine, 1,2-diaminoethane, 1,3-diaminopropane, 3-aminopiperidine or 3-aminopyrrolidine. The diamine is optionally substituted by one or more substituents on nitrogen or carbon atoms selected from alkyl, hydroxyalkyl, haloalkyl. The invention also relates to a method for tumour growth inhibition, comprising tumour cells with contacting by effective amount of 2-carboxamide derivatives of heteroarenanthracenediones.

EFFECT: blocking of the tumour cells growth.

5 cl, 1 tbl, 8 ex