FIELD: medicine.
SUBSTANCE: enzyme-linked immunosorbent assay (ELISA) is used to measure a patient's blood tissue inhibitor of metalloproteinase 1 (TIMP 1) and a terminal fragment of the Brain Natriuretic Peptide (NT pro BNP). A polymerase chain reaction (PCR) is used to determine genotypes of polymorphic variants of G894T gene of endothelial NO-syntase (NOS3) and A(-1903)G gene of chymase (CMA1). If TIMP 1 =< 635.7 ng/ml, NT pro BNP => 42.56 pmole/ml in a combination with the genotype g/t G894T NOS3 and the genotype a/g A(-1903)G CMA1, the unfavourable outcome of the disease is stated.
EFFECT: predicting the unfavourable outcome of hypertrophic cardiomyopathy before the first clinical symptoms and promoting more effective primary prevention of the sudden cardiac death and other essential complications of the disease.
2 tbl, 3 ex
| Title | Year | Author | Number |
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| METHOD OF TREATING PATIENT WITH HYPERTROPHIC CARDIOMYOPATHY | 2013 |
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