DIAGNOSTIC TECHNIQUE FOR GENETIC PREDISPOSITION TO CARDIAC CONDUCTION DISORDER Russian patent published in 2014 - IPC G01N33/68 

FIELD: medicine.

SUBSTANCE: genotypes of candidate genes of a cardiovascular pathology are analysed: polymorphisms -44A/G of Cx40 gene, A/G of SCN5A gene, VNTR4a/4b of NOS3 gene and I/D of ADRα2β gene. The genotypes -44GG of Cx40 gene, AA of SCN5A gene, 4a/4a of NOS3 gene and II of ADRα2β gene are assigned with 0%. The moderate-risk genotypes are 44AG of Cx40 gene, AG of SCN5A gene, 4a/4b of NOS3 gene and ID of ADRα2β genes and assigned with 50%. The high-risk genotypes are -44AG of Cx40 gene, GG of SCN5A gene, 4b/4b of NOS3 gene and DD of ADRα2β genes and assigned with 100%. The risk of cardiac conduction disorders is evaluated by formula. The risk is considered to be low with the values of 0% to 30%, moderate - of 30% to 60%, and high - more than 60%.

EFFECT: technique enables recovering the genetic markers of primary cardiac conduction disorders: sinus node disease, atrioventricular block, complete right bundle branch block, left bundle branch block and higher quality of diagnosing genetic predisposition to the above pathologies.

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