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2 611 399

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(51)

IPC

A61K38/03(2006-01-01)

G01N33/68(2006-01-01)

(21) (22)

Application

2016101410, 2016-01-19

(24)

Start date

2016-01-19

(22)

Actual filing date

2016-01-19

(45)

Published

2017-02-21

(72)

Inventor

Andreev Sergej MikhajlovichShilovskij Igor PetrovichSundukova Mariya SergeevnaMaerle Artem VladimirovichSergeev Ilya Viktorovich

(73)

Holder

Federalnoe Gosudarstvennoe Byudzhetnoe Uchrezhdenie Nauchnyj Tsentr Immunologii" Federalnogo Mediko-Biologicheskogo Agentstva Rossii

LABELLED DENDRIMER PEPTIDES Russian patent published in 2017 - IPC A61K38/03 G01N33/68

Abstract RU 2611399 C1

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention relates to medicine, namely to molecular pharmacology, and can be used for obtaining labelled cationic dendrimer peptides for intracellular delivery of nucleic acids (NA). Labelled cationic dendrimer peptides are represented by formula: X-AC(Y)-NH₂, where X is dendrimer cationic peptide with amino acid composition, selected from the group, consisting of (K)₄(K)₂K, (R)₈(K)₄(K)₂K, (RRRKK)₂KKK and (K₈)(K₄)(K₂)K, where K represents lysine; R represents arginine, A represents alanine, C represents cycteine, Y represents fluorescent cyanine dye Cy5 connected on cysteine mercaptogroup.

EFFECT: application of the claimed construction of labelled dendrimer peptides, which have binding unit for interaction with NA, and signal unit, containing fluorescent label - cyanine dye Cy5, makes it possible to visualise distribution of preparation in organis and tissues, providing transfection activity, close to transfection activity of complexes of nucleic acid with non-labelled dendrimer peptide.

6 dwg, 1 tbl, 3 ex

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RU 2 611 399 C1

Authors

Andreev Sergej Mikhajlovich

Shilovskij Igor Petrovich

Sundukova Mariya Sergeevna

Maerle Artem Vladimirovich

Sergeev Ilya Viktorovich

Dates

2017-02-21—Published

2016-01-19—Filed